منابع مشابه
Comparative safety of antiepileptic drugs during pregnancy.
OBJECTIVE To assess the safety of the newer antiepileptic drugs (AEDs) during pregnancy. METHODS The study population was pregnant women who enrolled in the North American AED Pregnancy Registry between 1997 and 2011. Data on AED use and maternal characteristics were collected through phone interviews at enrollment, at 7 months' gestation, and postpartum. Malformations were confirmed by medic...
متن کاملAre newer antiepileptic drugs associated with improved safety in pregnancy compared to older antiepileptic drugs?
Commentary As a group, antiepileptic drugs (AEDs) are associated with an increased risk of major congenital malformations (MCMs) (1). Older AEDs are the best studied. Valproate (VPA) is consistently associated with an increased risk of MCMs including an increased risk of spina bifida (2). Phenobarbital (PB) exposure increases the risk of MCMs, including oral clefts (3). Although not consistent ...
متن کاملAntiepileptic drug use during pregnancy: Perinatal outcomes
PURPOSE This study was undertaken to (1) measure the frequency of AED monotherapy or polytherapy during pregnancy and AED discontinuation prior to pregnancy in a cohort of women with treated epilepsy; and (2) describe the frequency of major congenital malformations according to maternal use of AED during pregnancy. METHODS A cohort of epileptic pregnant women was identified within the Quebec ...
متن کاملEURAP: an international registry of antiepileptic drugs and pregnancy.
Editor’s note—Several pregnancy registries presently are collecting data on pregnancy outcomes in women with epilepsy. Such registries have inherent limitations of selection bias and incomplete information. Data from the registries cannot easily be combined to achieve greater statistical power, since each registry differs from the other in methodology. Nevertheless, in the likely continued abse...
متن کاملCombining adverse pregnancy and perinatal outcomes for women exposed to antiepileptic drugs during pregnancy, using a latent trait model
BACKGROUND Application of latent variable models in medical research are becoming increasingly popular. A latent trait model is developed to combine rare birth defect outcomes in an index of infant morbidity. METHODS This study employed four statewide, retrospective 10-year data sources (1999 to 2009). The study cohort consisted of all female Florida Medicaid enrollees who delivered a live si...
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ژورنال
عنوان ژورنال: Obstetrical & Gynecological Survey
سال: 2012
ISSN: 0029-7828
DOI: 10.1097/01.ogx.0000425645.18736.d8